Injury Report Breakdown: Key Updates for 49ers vs. Eagles NFC Wild Card Showdown 2025

As the San Francisco 49ers gear up for their NFC Wild Card playoff encounter against the Philadelphia Eagles, injury concerns are at the forefront of their preparations. Head Coach Kyle Shanahan has indicated that several important players are currently listed as questionable following minor injuries sustained in the final regular-season game. Notably, cornerback Charvarius Ward is managing a persistent hamstring strain, while linebackers Dre Greenlaw and Fred Warner are coping with joint discomfort but are tentatively expected to participate after final assessments.

Below is a detailed overview of the 49ers’ injury situation that could influence their game-day roster:

Offensive lineman Trent Williams has been declared fit and will bring valuable veteran presence to the offensive front. The 49ers’ medical team remains hopeful, but the coaching staff is preparing alternative strategies, including defensive coverage adjustments and increased utilization of running backs, to mitigate any last-minute absences. With playoff intensity escalating, every roster decision will be critical for San Francisco’s bid to advance.

The Philadelphia Eagles face their own injury hurdles as they approach the NFC Wild Card Round. Quarterback Jalen Hurts is currently questionable due to an ankle sprain that could hamper his mobility and effectiveness against a formidable 49ers defense. Additionally, starting cornerback James Bradberry is contending with a knee injury that might restrict his ability to cover San Francisco’s versatile receiving unit.

Other significant injury updates for the Eagles include:

• Running back Kenneth Gainwell – Under concussion protocol, with an uncertain status
• Wide receiver A.J. Brown – Hamstring tightness, anticipated to play but possibly limited
• Linebacker Haason Reddick – Shoulder soreness, status questionable for game day

For the 49ers, quarterback Brock Purdy remains a focal point, with his agility and precision playing a pivotal role in the team’s offensive output this season. Despite a minor ankle issue reported during practice, Purdy is slated to start, offering a significant offensive threat. Defensively, edge rusher Nick Bosa continues to be a disruptive force, expected to pressure Eagles quarterback Jalen Hurts relentlessly.

Meanwhile, the Eagles will depend heavily on Jalen Hurts’ dual-threat capabilities, which consistently challenge opposing defenses. His health status will be a determining factor in Philadelphia’s offensive strategy. Defensively, linebacker T.J. Edwards has emerged as a key contributor, known for his tackling prowess and coverage skills, which will be essential in countering the 49ers’ multifaceted offense.

In light of the injury challenges, both teams are expected to modify their game strategies to address roster limitations. The 49ers may increase reliance on their defensive depth, particularly in the secondary, where injuries have reduced options. Defensive coordinator adjustments could include more frequent blitzes and aggressive coverage tactics designed to generate turnovers and compensate for personnel gaps. Offensively, San Francisco is likely to emphasize the running game, leveraging versatile backs to exploit weaknesses in the Eagles’ front seven and to alleviate pressure on their quarterback.

Conversely, the Eagles are anticipated to focus on strengthening offensive line cohesion and capitalizing on favorable matchups created by the 49ers’ defensive injuries. Their quarterback strategy will likely prioritize quick-release throws and screen passes to counteract pass rush pressure and maintain offensive momentum. Special teams may also play a heightened role, as Philadelphia aims to control field position and gain late-game advantages.