By Olivia WilliamsOctober 9, 2025 Sports San Francisco 49ers vs. Seattle Seahawks: Your Ultimate Guide to Watching Live, Kickoff Time, and Betting Odds for Week 1, 2025 The San Francisco 49ers face the Seattle Seahawks in Week 1 of the 2025 NFL season. Catch the live stream, TV channel details, start time, and latest betting odds for this fierce NFC West showdown on Niners Wire.